abstract：:Several members of the mitogen-activated protein kinase kinase kinase (MAP3K) family including MEKK3 and TGFbeta-activating kinase (TAK1) play nonredundant roles in activation of the NF-kappaB transcription factor. However, the mechanism by which MEKK3 mediates NF-kappaB signaling is not fully understood. In this repo...

journal_title：Cellular signalling

authors： Di Y,Li S,Wang L,Zhang Y,Dorf ME

更新日期：2008-04-01 00:00:00

abstract：:Phagocytosis is an essential event in the complex process of tissue repair. Here we examined the effect of low intensity pulsed ultrasound (US), which promotes fracture and wound healing, on phagocytosis by mouse macrophage cell line J774A.1 and human monocyte-derived macrophages. First, 10 to 40 min low intensity pul...

journal_title：Cellular signalling

authors： Zhou S,Bachem MG,Seufferlein T,Li Y,Gross HJ,Schmelz A

更新日期：2008-04-01 00:00:00

abstract：:Strong evidence suggests that neutrophils may play an active role in acute and chronic inflammatory disorders, such as rheumatoid arthritis and atherosclerosis. Given the role of pro-inflammatory cytokine TNF-alpha in these inflammatory processes, we planned the present study to investigate the effect of short term in...

journal_title：Cellular signalling

authors： Montecucco F,Steffens S,Burger F,Da Costa A,Bianchi G,Bertolotto M,Mach F,Dallegri F,Ottonello L

更新日期：2008-03-01 00:00:00

abstract：:Calcium has long been recognized as an important regulator of cell cycle transitions although the mechanisms are largely unknown. A functional genomic screen has identified genes involved in the regulation of early cell cycle progression by calcium. These genes when overexpressed confer the ability to bypass the G1/S ...

journal_title：Cellular signalling

authors： Lastro M,Kourtidis A,Farley K,Conklin DS

更新日期：2008-02-01 00:00:00

abstract：:The complex dynamic structure of the plasma membrane plays critical roles in cellular signaling; interactions with the membrane lipid milieu, spatial segregation within and between cellular membranes and/or targeting to specific membrane-associated scaffolds are intimately involved in many signal transduction pathways...

journal_title：Cellular signalling

authors： Eisenberg S,Henis YI

更新日期：2008-01-01 00:00:00

abstract：:Epac1 is a cAMP-stimulated guanine exchange factor that activates Rap1. The protein product of the T cell leukemia 1 (TCL1) proto-oncogene binds to Akt enhancing its kinase activity. TCL1 and Epac promote cellular proliferation because of their activating effects on Akt. Employing macrophages, we have studied the mech...

journal_title：Cellular signalling

authors： Misra UK,Kaczowka SJ,Pizzo SV

更新日期：2008-01-01 00:00:00

abstract：:Self-renewing divisions of normal and cancerous stem cells are responsible for the initiation and maintenance of normal and certain cancerous tissues, respectively. Recent findings suggest that tumor surveillance mechanisms can reduce regenerative capacity and frequency of normal stem cells, thereby contributing to ti...

journal_title：Cellular signalling

authors： Grinstein E,Wernet P

更新日期：2007-12-01 00:00:00

abstract：:Bim(EL) the most abundant Bim splice variant, is subject to ERK1/2-catalysed phosphorylation, which targets it for ubiquitination and proteasome-dependent destruction. In contrast, inactivation of ERK1/2, following withdrawal of survival factors, promotes stabilization of Bim(EL). It has been proposed that the RING fi...

journal_title：Cellular signalling

authors： Wiggins CM,Band H,Cook SJ

更新日期：2007-12-01 00:00:00

abstract：:Interleukin-1 (IL-1) is the major prototypic proinflammatory cytokine that stimulates degradation of cartilage in arthritis by inducing prominent collagen II-degrading matrix metalloproteinase-13 (MMP-13). Nothing is known about the involvement of adaptor proteins, MyD88, IRAK1 and TRAF6 in MMP-13 regulation. Here we ...

journal_title：Cellular signalling

authors： Ahmad R,Sylvester J,Zafarullah M

更新日期：2007-12-01 00:00:00

abstract：:Members of the phosducin gene family were initially proposed to act as down-regulators of G protein signaling by binding G protein betagamma dimers (Gbetagamma) and inhibiting their ability to interact with G protein alpha subunits (Galpha) and effectors. However, recent findings have over-turned this hypothesis by sh...

journal_title：Cellular signalling

authors： Willardson BM,Howlett AC

更新日期：2007-12-01 00:00:00

abstract：:Chemotaxis plays an important role in metastasis of cancer cells. In the current study, we investigated the role of PTEN, a tumor suppressor, in chemotaxis of human breast cancer cells. Over-expression of PTEN inhibited EGF-induced chemotaxis, probably due to an overall reduction of PIP(3) levels. Disruption of PTEN b...

journal_title：Cellular signalling

authors： Wan W,Zou H,Sun R,Liu Y,Wang J,Ma D,Zhang N

更新日期：2007-11-01 00:00:00

abstract：:Platelet-activating factor (PAF) is a potent phospholipid mediator involved in several diseases such as allergic asthma, atherosclerosis and psoriasis. The human PAF receptor (PAFR) is a member of the G-protein-coupled receptor family. Following stimulation, PAFR becomes rapidly desensitized; this refractory state is ...

journal_title：Cellular signalling

authors： Dupré DJ,Thompson C,Chen Z,Rollin S,Larrivée JF,Le Gouill C,Rola-Pleszczynski M,Stanková J

更新日期：2007-10-01 00:00:00

abstract：:Mitogen-activated protein kinases (MAPKs) are not only pivotal mediators of signal transduction but they also regulate diverse biological processes ranging from survival, proliferation and differentiation to apoptosis. By using human U87 astrocytoma and transfected FPRL1/CHO cells, we have demonstrated that activation...

journal_title：Cellular signalling

authors： Kam AY,Tse TT,Kwan DH,Wong YH

更新日期：2007-10-01 00:00:00

abstract：:Oxidative stress is an increase in the reduction potential or a large decrease in the reducing capacity of the cellular redox couples. A particularly destructive aspect of oxidative stress is the production of reactive oxygen species (ROS), which include free radicals and peroxides. Some of the less reactive of these ...

journal_title：Cellular signalling

authors： Genestra M

更新日期：2007-09-01 00:00:00

abstract：:Despite the essential role of the fibrinogen gamma-chain as a blood clotting factor, the fibrinogen gamma-chain contains a number of interaction sites to recruit other factors such as leukocytes important for prevention of pathogen entry and propagation of the repair process. Interleukin-6 (IL-6) is known as the major...

journal_title：Cellular signalling

authors： Albrecht U,Yang X,Asselta R,Keitel V,Tenchini ML,Ludwig S,Heinrich PC,Häussinger D,Schaper F,Bode JG

更新日期：2007-09-01 00:00:00

abstract：:Nuclear factor of activated T cells (NFAT) plays a prominent role in gene transcription during the immune response. Growing evidence demonstrates the implication of inducible phosphorylation of the transactivation domain (TAD) of NFAT in transcriptional activation of genes. We have analyzed the regulation of NFATc2 ac...

journal_title：Cellular signalling

authors： Gómez-Casero E,San-Antonio B,Iñiguez MA,Fresno M

更新日期：2007-08-01 00:00:00

abstract：:Mitogen-activated protein (MAP) kinase cascades are signal transduction pathways that play pivotal regulatory roles in the biosynthesis of pro-inflammatory cytokines. MAP kinase phosphatase (MKP)-1, an archetypal member of the MKP family, is essential for the dephosphorylation/deactivation of MAP kinases p38 and JNK. ...

journal_title：Cellular signalling

authors： Wang X,Liu Y

更新日期：2007-07-01 00:00:00

abstract：:Toll-like-receptor mediated signaling is finely regulated by a complex intracellular protein network including the interleukin-1 receptor associate kinases (IRAKs). IRAK-4, 1, and 2 may positively regulate innate immunity signaling through the activation of various downstream kinases such as MAPKs. In contrast, IRAK-M...

journal_title：Cellular signalling

authors： Su J,Xie Q,Wilson I,Li L

更新日期：2007-07-01 00:00:00

abstract：:The functional role of peroxisome proliferator-activated receptor-beta(PPARbeta; also referred to as PPARdelta) in epidermal cell growth remains controversial. Recent evidence suggests that ligand activation of PPARbeta/delta increases cell growth and inhibits apoptosis in epidermal cells. In contrast, other reports s...

journal_title：Cellular signalling

authors： Burdick AD,Bility MT,Girroir EE,Billin AN,Willson TM,Gonzalez FJ,Peters JM

更新日期：2007-06-01 00:00:00

abstract：:Acute myeloid leukemia (AML) cell lines treated by genotoxic agents or by Tumor Necrosis Factor alpha (TNFalpha) acquire potent cytotoxicity towards myeloid cells through activation of granzyme B (GrB)/perforin (PFN) system. Here we first extend this observation to another death receptor activator, Fas Ligand (FasL). ...

journal_title：Cellular signalling

authors： Guilloton F,Jean C,de Thonel A,Laurent G,Quillet-Mary A

更新日期：2007-06-01 00:00:00

abstract：:Arap3 is a phosphoinositide (PI) 3 kinase effector that serves as a GTPase activating protein (GAP) for both Arf and Rho G-proteins. The protein has multiple pleckstrin homology (PH) domains that bind preferentially phosphatidyl-inositol-3,4,5-trisphosphate (PI(3,4,5,)P3) to induce translocation of Arap3 to the plasma...

journal_title：Cellular signalling

authors： Raaijmakers JH,Deneubourg L,Rehmann H,de Koning J,Zhang Z,Krugmann S,Erneux C,Bos JL

更新日期：2007-06-01 00:00:00

abstract：:Disabled-2 (DAB2) is an adapter protein that plays a key role in cell proliferation and differentiation. We reported here that DAB2 is expressed in various regions of rat central nervous system and is most abundant in the olfactory bulb. The up-regulation of DAB2 upon 5,7-dihydroxytryptamine-induced spinal cord lesion...

journal_title：Cellular signalling

authors： Huang CH,Cheng JC,Chen JC,Tseng CP

更新日期：2007-06-01 00:00:00

abstract：:Previous studies from acutely transfected HeLa cells have identified an acidic alpha-helix in the Type IIbeta PtdIns5P 4-kinase (PIPkin IIbeta) as a putative novel nuclear localisation sequence (Ciruela et al. Biochem. J. 364, 587-591 2000). However, some heterogeneity in cellular localisation was always observed, and...

journal_title：Cellular signalling

authors： Richardson JP,Wang M,Clarke JH,Patel KJ,Irvine RF

更新日期：2007-06-01 00:00:00

abstract：:Smac/DIABLO is a mitochondrial protein that participates in apoptotic cell death by means of sequestering several members of the inhibitor of apoptosis protein family. This action allows caspase activation, cleavage of key cellular substrates and death. Release from mitochondria is considered the main regulatory step ...

journal_title：Cellular signalling

authors： Martinez-Velazquez M,Melendez-Zajgla J,Maldonado V

更新日期：2007-06-01 00:00:00

abstract：:As a member of the Rab small GTPase family, Rab11a has been shown to be involved in different vesicle trafficking processes. In earlier work we identified Rab11a to be present in GLUT4-containing vesicles after insulin stimulation and showed its involvement in insulin-dependent glucose uptake. However, it remained elu...

journal_title：Cellular signalling

authors： Schwenk RW,Eckel J

更新日期：2007-04-01 00:00:00

abstract：:PI3K signalling pathways link cell surface receptors to the control of several intracellular functions including cell growth, survival and movement. Filamins are important regulators of cortical actin structure and function. LL5beta is a filamin binding protein that is an effector of the PI3K signalling pathway. We de...

journal_title：Cellular signalling

authors： Paranavitane V,Stephens LR,Hawkins PT

更新日期：2007-04-01 00:00:00

abstract：:Mice lacking the gene for suppressor of cytokine signaling 1 (SOCS1) show defective homeostasis of T lymphocytes due to accumulation of CD8(+) T cells, resulting at least partly from dysregulated IL-15 signaling. IL-15 alone does not stimulate proliferation of naïve CD8 T cells, but can synergize with IL-21 to induce ...

journal_title：Cellular signalling

authors： Gagnon J,Ramanathan S,Leblanc C,Ilangumaran S

更新日期：2007-04-01 00:00:00

abstract：:The duration of ERK1/2 activation influences the nature of the biological response to agonist. Members of the AP-1 transcription factor family are well known targets of the ERK1/2 pathway and are expressed in a temporally coordinated fashion during cell cycle re-entry. In CCl39 fibroblasts, sustained ERK1/2 activation...

journal_title：Cellular signalling

authors： Chalmers CJ,Gilley R,March HN,Balmanno K,Cook SJ

更新日期：2007-04-01 00:00:00

abstract：:Ionizing radiation elicits signaling events that coordinate DNA repair and interruption of cell cycle progression. We previously demonstrated that ionizing radiation (IR) of cells activates nuclear protein phosphatase-1 (PP1) by promoting dephosphorylation of Thr320, an inhibitory site in the enzyme and that the ATM k...

journal_title：Cellular signalling

authors： Guo C,Mi J,Brautigan DL,Larner JM

更新日期：2007-03-01 00:00:00

abstract：:Wnt3a activates proliferation of fibroblasts cells via activation of both extracellular signal-regulated kinase (ERK) and Wnt/beta-catenin signaling pathways. In this study, we show that the phosphatidyl inositol 3 kinases (PI3K)-Akt pathway is also involved in the Wnt3a-induced proliferation. Akt was activated within...

journal_title：Cellular signalling

authors： Kim SE,Lee WJ,Choi KY

更新日期：2007-03-01 00:00:00

abstract：:The effects of estrogen in breast epithelial cells are mediated primarily via estrogen receptor alpha and estrogen receptor beta (ERalpha and ERbeta). Accumulating evidence implicates a role for Ca2+ and calmodulin in breast carcinoma, as well as in the function of ERalpha. Calmodulin contributes to the regulation of ...

journal_title：Cellular signalling

authors： Li L,Sacks DB

更新日期：2007-03-01 00:00:00

abstract：:Phosphatidic acid, the product of phospholipase D catalysed phosphatidylcholine hydrolysis is an important signalling molecule that has been implicated in regulation of actin cytoskeleton remodelling and secretion from mast cells. We show that human PLD1b (hPLD1b) is an actin-binding protein and the N-terminus is pred...

journal_title：Cellular signalling

authors： Farquhar MJ,Powner DJ,Levine BA,Wright MH,Ladds G,Hodgkin MN

更新日期：2007-02-01 00:00:00

abstract：:Protein Kinase B (PKB/Akt) is a key regulator of cell proliferation, motility and survival. The activation status of PKB is regulated by phosphatidylinositol 3-kinase (PI3K) via the synthesis of phosphatidylinositol-3,4,5-trisphosphate (PI(3,4,5)P3, PIP3). PTEN antagonises PI3K by degrading PIP3 to phosphatidylinosito...

journal_title：Cellular signalling

authors： Sharrard RM,Maitland NJ

更新日期：2007-01-01 00:00:00

abstract：:Skeletal muscle is highly adapted to respond to oxidative imbalances, since it is continuously subjected to an increased production of reactive oxygen species (ROS) during exercise. Oxidative stress, however, has been associated with skeletal muscle atrophy and damage in many diseases. In this study, we examined wheth...

journal_title：Cellular signalling

authors： Kefaloyianni E,Gaitanaki C,Beis I

更新日期：2006-12-01 00:00:00

abstract：:The attachment of spindle microtubules to kinetochores is crucial for accurate segregation of chromosomes to daughter cells during mitosis. While a growing number of proteins involving this step are being identified, its molecular mechanisms are still not clear. Here we show that protein kinase C zeta (PKCzeta) is loc...

journal_title：Cellular signalling

authors： Liu XF,Xie X,Miki T

更新日期：2006-12-01 00:00:00

abstract：:The interferon-induced double-stranded RNA (dsRNA)-activated protein kinase (PKR) has been shown to activate NF-kappaB independently of its kinase function after interaction with the IKK complex. In order to investigate the mechanism of NF-kappaB activation by PKR, we identified the domain of PKR responsible for stimu...

journal_title：Cellular signalling

authors： Bonnet MC,Daurat C,Ottone C,Meurs EF

更新日期：2006-11-01 00:00:00

abstract：:RAW macrophages, which express the PDE4D3 and PDE4D5 cAMP phosphodiesterase isoforms, exhibited increased PDE4 activity when challenged with H2O2 in a fashion that was negated by treatment with the cell permeant antioxidant, N-acetyl cysteine and by diphenyleneiodonium chloride, an inhibitor of NADPH oxidase. In Cos1 ...

journal_title：Cellular signalling

authors： Hill EV,Sheppard CL,Cheung YF,Gall I,Krause E,Houslay MD

更新日期：2006-11-01 00:00:00

abstract：:Rho GTPases are molecular switches involved in the regulation of many cellular processes. This review summarizes work examining how stimulation of receptor tyrosine kinases (RTKs) leads to the activation of Rho guanine nucleotide exchange factors (GEFs) and their Rho GTPase substrates. The collective findings strongly...

journal_title：Cellular signalling

authors： Schiller MR

更新日期：2006-11-01 00:00:00

abstract：:Cyclic mechanical stretch associated with pulsatile blood pressure can modulate cytoskeletal remodeling and intracellular signaling in vascular endothelial cells. The aim of this study was to evaluate the role of stretch-induced actin stress fiber orientation in intracellular signaling involving the activation of c-ju...

journal_title：Cellular signalling

authors： Kaunas R,Usami S,Chien S

更新日期：2006-11-01 00:00:00

abstract：:Nore1A was originally identified as a potential Ras effector, and Nore1B is an alternatively spliced isoform. Both share a Ras/Rap association domain (RA domain) but only Nore1A contains sequence motifs that predict SH3 domain binding and diacylglycerol/phorbol ester binding in the amino-terminal region. Here we repor...

journal_title：Cellular signalling

authors： Ishiguro K,Avruch J,Landry A,Qin S,Ando T,Goto H,Xavier R

更新日期：2006-10-01 00:00:00